个人简介
柳云恩，男，1979年出生，医学博士/博士后，教授，主任医师，硕士研究生导师，沈阳医学院树人国际学院副院长，辽宁省皮肤粘膜软组织创伤修复重建重点实验室和沈阳市消化系统损伤修复重点实验室执行主任。所属二级学科/领域：病理学与病理生理学。2012年于中国医科大学获得肿瘤学博士学位。荣获“沈阳市高层次领军人才（C类）”和“第十五届沈阳市优秀科技工作者”荣誉称号。担任辽宁省科技厅、广东省科技厅、江西省科技厅和沈阳市科技局科技项目评审专家，香港科技大学顾问、辽宁省科协科技人才奖项评审专家、沈阳市科协科技创新智库第一批入库专家、沈阳市标准化专家、沈阳市大学生创新创业导师和CNKI项目评审专家。现任辽宁省细胞生物学会细胞损伤修复与组织重建专委会主任委员、中国医药技术协会皮肤软组织修复重建技术分会常务委员、世界中联经皮给药专业委员会常务理事、《Medical Gas Research》青年编委、《中华烧伤与创面修复杂志》编委、《临床军医杂志》编委、《创伤与急危重病医学杂志》编委和《中国生物医药杂志》编委。主持及参与军委后勤保障部重大项目、军委科技委基础加强重大项目、国家自然科学基金项目、辽宁省科技厅联合基金项目、辽宁省教育厅重点项目、广东省重点研发计划和省市级各类项目40多项，累计申请经费4500多万。在《Theranostics》、《ACS Appl Mater Interfaces》、《J MATER SCI TECHNOL》和《Free Radic Biol Med》等国外期刊发表SCI论文58篇，影响因子356.28；在《中华医学杂志》、《中华急诊杂志》和《中华创伤杂志》等核心期刊发表论文136篇；参编专著6部；申请专利27项，其中发明专利8项、实用新型专利19项；荣获辽宁省科技进步二等奖1项、辽宁省自然科学学术成果一等奖1项、三等奖2项、沈阳市自然科学学术成果二等奖2项、三等奖1项。作为指导教师荣获第十四届“挑战杯”中国大学生创业计划竞赛辽宁赛区金奖、辽宁省中医药大健康竞赛一等奖、辽宁省中医药大健康竞赛三等奖和沈阳市创新创业创意大赛三等奖。
教育学习经历（按时间顺序）：
2013.08-2015.08 北部战区总医院 急诊医学 博士后
2009.09-2012.07 中国医科大学 肿瘤学 博士学位
2004.09-2007.07 中国医科大学 肿瘤学 硕士学位
1999.09-2004.07 沈阳医学院 临床医学 学士学位
科研与学术工作经历（按时间顺序）：
2021.07-至今 沈阳医学院树人国际学院，教授，副院长
2013.04-2021.10 北部战区总医院，副主任医师，实验室主任
2012.04-2013.04 原沈阳军区总医院，病理科主治医师
2007.07-2012.04 国家（沈阳）新药安全评价研究中心，工程师
研究方向：
组织损伤修复与医工融合转化研究
主要学术任职：
沈阳医学院学术委员会委员；辽宁省细胞生物学会细胞损伤修复与组织重建专委会主任委员；中国医药技术协会皮肤软组织修复重建技术分会常务委员；世界中联经皮给药专业委员会常务理事；《Medical Gas Research》青年编委、《中华烧伤与创面修复杂志》编委；《临床军医杂志》编委；《创伤与急危重病医学杂志》编委和《中国生物医药杂志》编委。
近五年主持的课题：
[1] 2022年军委科技委基础加强重大项目，等离子体治疗创伤评价（20224242112），2022.8-2025.2，资助资金225万，子课题负责人
[2] 2022年辽宁省科技厅联合基金项目：等离子体活化水联合生物多糖治疗难愈合性皮肤创面的作用机制研究（2022-NLTS-14-03），2022.9-2024.8，资助资金20万，项目负责人
[3] 2021年辽宁省教育厅重点项目：适用于人员皮肤创伤表面的快速等离子体消毒技术及装置研究（No. LJKZ1153），2021.06-2024.05，资助资金10万，项目负责人
[4] 2021年辽宁省教育厅面上项目：适用于人员皮肤创伤表面的快速等离子体消毒技术及装置研究（No. LJKZ1153），2021.06-2024.05，资助资金3万，项目负责人
[5] 2022年沈阳市自然科学基金（基础研究）专项：多孔甲壳质纳米纤维干细胞支架修复慢性难愈合创面的机制研究（22-315-6-17），2022.1-2024.12，资助经费50万元，项目负责人
[6] 中南大学湘雅医院，校院合作，高粘附促神经修复Janus水凝胶的制备及修复机制研究，2024.01-2026.01，84万元，项目负责人
[7] 鞍钢集团公司总医院，校院合作，低温大气压等离子体联合血管内介入治疗糖尿病足合并下肢动脉闭塞患者的有效性与安全性：一项随机、双盲、安慰剂对照的单中心临床试验（KJK2024003），2024.1.5-2027.8.31，25万元，项目负责人
[8] 校企合作项目，水凝胶负载干细胞来源的外泌体修复糖尿病慢性创面的机制研究（20230303），2023.1-2024.12，资助经费50万元，项目负责人
[9] 辽宁中医药大学“中医脏象理论及应用教育部重点实验室”开放基金课题计划项目，基于“培土通脉”法探讨黄芪—三七组方经皮递药系统的构建及其修复糖尿病慢性创面的协同增效机制（zyzx2209），2023.1-2024.12，资助经费5万元，项目负责人
近五年代表性论著：
[1] Zhu Y, Hu Z, Liu Y, Yan T, Liu L, Wang Y, Bai B. AChE activity self-breathing control mechanisms regulated by H2Sn and GSH: Persulfidation and glutathionylation on sulfhydryl after disulfide bonds cleavage. Int J Biol Macromol. 2024;259(Pt 2):129117.
[2] Luo Z, Xu J, Gao Q, Wang Z, Hou M, Liu Y. Study on the effect of licochalcone A on intestinal flora in type 2 diabetes mellitus mice based on 16S rRNA technology. Food Funct. 2023;14(19):8903-8921.
[3] Xu Y, Ren X, Jiang T, Lv S, Gao K, Liu Y, Yan Y. Circulating tumor cells (CTCs) and hTERT gene expression in CTCs for radiotherapy effect with lung cancer. BMC Cancer. 2023;23(1):475.
[4] Wu M, Mao S, Liu X, Liu Y, Cong P, Lv J, Tian H, Zhao Y. Strong tissue adhesive polyelectrolyte complex powders based on low molecular weight chitosan for acute hemorrhage control. Int J Biol Macromol. 2023:248:125755.
[5] Zhang Q, Liu Y, Wang X, Zhang C, Hou M, Liu Y. Integration of single-cell RNA sequencing and bulk RNA transcriptome sequencing reveals a heterogeneous immune landscape and pivotal cell subpopulations associated with colorectal cancer prognosis. Front Immunol. 2023:14:1184167.
[6] Zhang R, Liu Y, You J, Ge B. Tanshinone IIA inhibits ischemia-reperfusion-induced inflammation, ferroptosis and apoptosis through activation of the PI3K/Akt/mTOR pathway. Hum Exp Toxicol. 2023 Jan-Dec:42:9603271231180864.
[7] Zhang J, Luo Z, Zhang Z, Zhao M, Tong C, Cong P, Mao S, Zhao Y, Hou M, Piao Y, Liu Y. Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice. Chem Biol Interact. 2022;365:110079.
[8] Lv J, Ou X, Fang Y, Wu M, Zheng F, Shang L, Lei K, Liu Y, Zhao Y. The Study of Deep Eutectic Solvent Based on Choline Chloride and L-(+)-Tartaric Acid Diethyl Ester for Transdermal Delivery System. AAPS PharmSciTech. 2022 8;23(7):252.
[9] Kang K, Liu Y, Song X, Xu L, Zhang W, Jiao Y, Zhao Y. Hemostatic Performance of ɑ-Chitin/Gelatin Composite Sponges with Directional Pore Structure. Macromol Biosci. 2022; 22(7): e2200020.
[10] Zhang Y, Wang Y, Liu Y, Gong T, Hou M. The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice. Biomed Res Int. 2022; 2022:8746530.
[11] Liu Y, Tong C, Cong P, Liu Y, Shi X, Shi L, Mao S, Zhao Y, Jin H, Hou M. Proteomic Analysis Revealed the Characteristics of Key Proteins Involved in the Regulation of Inflammatory Response, Leukocyte Transendothelial Migration, Phagocytosis, and Immune Process during Early Lung Blast Injury[J]. Oxid Med Cell Longev, 2021, 2021:8899274.
[12] Xiaoqiang Song, Yan Zhao, Yunen Liu, Wenchang Zhang, Xiaoxue Yuan, Lei Xu, Jinsong Zhang. Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges. Carbohydr Polym, 2021; 273: 118615.
[13] Song X, Zhao Y, Liu Y, Zhang W, Yuan X, Xu L, Zhang J. Effects of degree of deacetylation on hemostatic performance of partially deacetylated chitin sponges. Carbohydr Polym, 2021; 273:118615.
[14] Li N, Cui W, Cong P, Tang J, Guan Y, Huang C, Liu Y, Yu C, Yang R, Zhang X. Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules. Bioact Mater, 2021; 6(8):2303-2314..
[15] Cong P, Tong C, Mao S, Shi L, Shi X, Liu Y, Jin H, Liu Y, Hou M. DDAH1 Promotes Lung Endothelial Barrier Repair by Decreasing Leukocyte Transendothelial Migration and Oxidative Stress in Explosion-Induced Lung Injury[J]. Oxid Med Cell Longev, 2022; 2022: 8407635.
[16] Zifeng Wang, Mengying Zhu, Dingxin Liu, Linbo Liu, Xiangyu Wang, Jinkun Chen, Li Guo1, Yunen Liu, Mingxiao Hou and Mingzhe Rong. N2O5 in air discharge plasma: energy-efficient production, maintenance factors and sterilization effects. J. Phys. D: Appl. Phys. 56 075204.
[17] Liu Y, Liu Y, Wu M, Zou R, Mao S, Cong P, Hou M, Jin H, Zhao Y, Bao Y. Adipose-derived mesenchymal stem cell-loaded β-chitin nanofiber hydrogel promote wound healing in rats. J Mater Sci Mater Med. 2022;33(2):12.
[18] Liu Y, Liu Y, Tong C, Cong P, Shi X, Shi L, Hou M, Jin H, Bao Y. Quantitative analysis of the global proteome in lung from mice with blast injury. Exp Lung Res. 2020;46(8):308-319.
[19] Tang Y, Ji Y, Yi C, Cheng D, Wang B, Fu Y, Xu Y, Qian X, Choonara YE, Pillay V, Zhu W, Liu Y, Nie Z. Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors. Theranostics. 2020 Jul 9;10(19):8691-8704.
[20] Feng Guo; Yunen Liu; Kai Jiao; Rui Yang; Mingxiao Hou; Xing Zhang. Artificial Heart Valves with Balanced Charged Networks Exhibiting Anti-Calcification Properties. ACS Applied Bio Materials Pub Date : 2020-01-02 , DOI: 10.1021/acsabm.9b00902.
[21] Guo X, Liu Y, Bera H, Zhang H, Chen Y, Cun D, Foderà V, Yang M. α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring. ACS Appl Mater Interfaces. 2020 14;12(41):45702-45713.
[22] Li N, Zhang EF, Zhang J, Zhang L, Liu YE, Jin HX, Gao Y, Hou LC. Therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy in mice. Int Immunopharmacol. 2020 Apr; 81:106280. doi: 10.1016/j.intimp.2020.106280.
[23] Kai Chena Changci Tong, JingeYang, Peifang Cong, Ying Liu, Xiuyun Shi,Xu Liu, Jun Zhang, Rufei Zou, Keshen Xiao, Yuyang Ni, Lei Xue, Mingxiao Hou, Hongxu Jin, Yunen Liu, Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition[J]. J MATER SCI TECHNOL, 2021, 63:236-245.
[24] Zhang W, Qi X, Zhao Y, Liu Y, Xu L, Song X, Xiao C, Yuan X, Zhang J, Hou M. Study of injectable Blueberry anthocyanins-loaded hydrogel for promoting full-thickness wound healing[J]. Int J Pharm, 2020, 586:119543.
[25] Cong P, Tong C, Liu Y, Shi L, Shi X, Zhao Y, Xiao K, Jin H, Liu Y, Hou M. CD28 Deficiency Ameliorates Thoracic Blast Exposure-Induced Oxidative Stress and Apoptosis in the Brain through the PI3K/Nrf2/Keap1 Signaling Pathway[J]. Oxid Med Cell Longev, 2019, 2019:8460290.
[26] Shang L, Pin L, Zhu S, Zhong X, Zhang Y, Shun M, Liu Y, Hou M. Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3β signaling pathway[J]. Chem Biol Interact, 2019; 307:21-28.
[27] Lv X, Liu Y, Song S, Tong C, Shi X, Zhao Y, Zhang J, Hou M. Influence of chitosan oligosaccharide on the gelling and wound healing properties of injectable hydrogels based on carboxymethyl chitosan/alginate polyelectrolyte complexes. Carbohydr Polym. 2019; 205:312-321.
[28] Liu Y, Tong C, Xu Y, Cong P, Liu Y, Shi L, Shi X, Zhao Y, Bi G, Jin H, Hou M. CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway[J]. Oxid Med Cell Longev, 2019, 2019: 4848560.
[29] Liu Y, Tong C, Tang Y, Cong P, Liu Y, Shi X, Shi L, Zhao Y, Jin H, Li J, Hou M. Tanshinone IIA alleviates blast-induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway[J]. Free Radic Biol Med, 2020, 152:52-60.
[30] Peifang Cong, Teng Wang, Changci Tong, Ying Liu, Lin Shi, Shun Mao, Xiuyun Shi, Hongxu Jin, Yunen Liu, Mingxiao Hou. Resveratrol ameliorates thoracic blast exposure-induced inflammation, endoplasmic reticulum stress and apoptosis in the brain through the Nrf2/Keap1 and NF-κB signaling pathway[J]. Injury, 2021; 52(10): 2795-2802.
[31] Zhang Y, Cong P, Tong C, Jin H, Liu Y, Hou M. Melatonin pretreatment alleviates blast-induced oxidative stress in the hypothalamic-pituitary-gonadal axis by activating the Nrf2/HO-1 signaling pathway[J]. Life Sci, 2021; 280: 119722.
[32] Zheng H, Shi L, Tong C, Liu Y, Hou M. circSnx12 Is Involved in Ferroptosis During Heart Failure by Targeting miR-224-5p[J]. Front Cardiovasc Med, 2021, 21; 8: 656093.
[33] Jun Zhang, Zhonghua Luo, Zhe Zhang, Meng Zhao, Changci Tong, Peifang Cong, Shun Mao, Yan Zhao, Mingxiao Hou, Ying Piao, Yunen Liu. Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice[J]. Chem Biol Interact. 2022; 365: 110079.
[34] Tong C, Cong P, Liu Y, Shi X, Shi L, Mao S, Zhao Y, Hou M, Liu Y. Tandem Mass Tag-Based Quantitative Proteomic Analysis Reveals Pathways Involved in Brain Injury Induced by Chest Exposure to Shock Waves[J]. Front Mol Neurosci, 2021; 14: 688050.
[35] Luo Z, Tong C, Cong P, Mao S, Xu Y, Hou M, Liu Y. Silencing CD28 attenuated chest blast exposure-induced traumatic brain injury through the PI3K/AKT/NF-κB signaling pathway in male mice. Brain Res Bull. 2024 Aug:214:110987. doi: 10.1016/j.brainresbull.2024.110987.
