个人简介
王天禄,男,1974年出生,博士研究生导师,主任医师,香港大学访问学者,辽宁省肿瘤医院胸部肿瘤放射治疗科主任,专注于肿瘤规范化治疗28年,与香港大学孔凤鸣教授(美国放射学院院士)团队“建立创新平台开展全新的个体化放射和免疫联合治疗”,进行影像/分子标志物引导的个体化放疗,肿瘤控制、生存或治疗相关毒性的研究和治疗。所属二级学科/领域:病理学与病理生理学/基础医学。2014年于中国医科大学获得肿瘤学专业博士学位。现任辽宁省生命科学学会肿瘤放射免疫治疗分会主任委员,辽宁省医学会放射肿瘤学分会副主任委员,辽宁省红十字基金会骨转移瘤医学专家委员会副主任委员;辽宁省细胞生物学学会肿瘤智能医疗专委会副主任委员;辽宁省生命科学学会医用生物材料专家协作委员会副主任委员;民盟沈阳市医药卫生工作委员会副主任委员,世界华人肿瘤医师协会肺癌工作委员会委员,辽宁省医学会医疗鉴定专家库成员,华人肿瘤放射治疗协作组放射免疫工作委员会委员。主持国家科技部、教育部、国家癌症中心及省部级课题12项,沈阳市重大科技创新研发计划项目1项,肿瘤质谱中心项目1 项,主持开展临床新技术项目7项。以第一/通讯作者在在Molecul ar Cance(中科院1区,IF:41.4)、TrAC (中科院1区,分析化学TOP1期刊,IF:14. 9)、Journal ofPharmaceutical Analysis (中科院1区,药物分析TOP1期刊,IF:14.0)等高水平期刊发表SCI论文25篇,国内核心期刊论文10余篇,累计影响因子158分,授权专利发明43项(第一发明人),签署转化协议1项(500万),5项专利实现技术成果转让,2017年和2018年分别获得辽宁省自然科学学术成果奖。名下研究生6人次获得一等奖学金、优秀研究生,4人次获得国家奖学金和辽宁省优秀毕业生,获国家级大学生创新创业项目1项,“红医杯”银奖3项。
教育学习经历(按时间顺序):
2023.01至2023.06 香港大学,放射肿瘤学,访问学者
2011-09至2014-07,中国医科大学,放射肿瘤学,博士
2005-09至2008-07,中国医科大学,放射肿瘤学,硕士
2002-09至2005-07,大连医科大学,临床医学,学士
科研与学术工作经历(按时间顺序):
2017-12至今, 辽宁省肿瘤医院,放疗科,主任医师
2012-12至2017-12,辽宁省肿瘤医院,放疗科,副主任医师
2008-09至2012-12,辽宁省肿瘤医院,放疗科,主治医师
1995-09至 2005-12,丹东市人民医院,影像科,医师
研究方向:
肺癌病理生理学、肿瘤放疗抵抗分子机制及治疗策略,纳米机器人肿瘤检测与治疗,人工智能在医学上的应用,进行肿瘤基础及临床转化研究。
近五年主持的课题:
(1)国家科技部,建立肺癌个体化放射和免疫联合治疗多中心临床试验平台,G2023127016L,2023.1.1-2024.12.31,主持;
(2)教育部,基于免疫生物标记物IDO1建立肺癌放射和免疫联合治疗创新临床试验平台,202311060014,2024.4.1-2025.3.30,主持;
(3)教育部,放射性口腔黏膜炎生理盐水对比液体伤口敷料的随机、平行对照试验,项目编号:2024GR072,2024.09-2025.08,主持;
(4)辽宁省科技厅:多维临床数据赋能的肺鳞癌精准放疗免疫分子分型的研究,项目编号:2024JH2/102600188,2025.1-2026.12,主持;
(5)医工交叉联合基金项目,面向肺癌围手术期康复监测的智能可穿戴电化学传感器研发,项目编号:LD202412,2025.1-2026.12,主持;
(6)辽宁省卫生健康委,面向基层卫生人才肿瘤防治核心知识及技能培训订单式服务及运行机制研究,项目编号:No.2024-N008-02,2024.12.24-2026.12.23,主持;
(7)辽宁省科技厅:基于纳米机器人原代癌细胞机械特性检测方法和预后模型研究,2019-KF-01-01,2019.10.1-2022.9.31,主持;
(8)辽宁省科技厅:外泌体物理特性信息检测及其在肺腺癌免疫治疗反应预测中的应用和机理研究,2020-ZLLH-47,2020.01.01-2022.12.31,主持;
(9)质谱中心项目:基于质谱检测分析联合大数据采用人工智能的方法进行肺癌诊疗终身模型的构建与开发,ZP202013,2020.1.1-2022.12.31,主持;
(10)辽宁省科技厅:胞外基质硬度通过细胞膜相关骨架结构调控肺鳞癌细胞迁移的机制研究,2021-YGJC-02,2021.1.1-2022.12.31,共同主持;
(11)沈阳市重大科技项目:基于人工智能与大数据的原发性肺癌智能专家辅助决策系统的开发与应用研究,19-112-4-090,2019.1.1-2021.12.31,结题,主持;
(12)辽宁省科技厅:DUSP6与肺鳞癌铂类耐药的机制研究,20180550741,2018.9.1-2021.8.31,结题,主持;
(13)国家癌症中心:应用[18F]fluorodeoxyglucose(FDG) PET/CT指导局部晚期非小细胞肺癌精确放疗的研究,NCC2017A08,2018.1.1-2020.12.31,结题,主持;
近五年代表性论著:
[1] Yu Wu,Yingqiu Song, Runze Wang, Tianlu Wang*, Molecular mechanisms of tumor resistance to radiotherapy, Molecular Cancer.2023,22:96.(Q1, IF:37.3)
[2] Liu Z, Zhang X, Ben T, Li M, Jin Y, Wang T*, Song Y*. Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets. Biomark Res. 2025 Mar 5;13(1):38.(Q2, IF:9.5)
[3]Shuang Ma, Junfeng Wu, Zhihua Liu, Rong He, Yuechao Wang, Lianqing Liu, Tianlu Wang*, Wenxue Wang*, Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication, Journal of Pharmaceutical Analysis.13 March 2023.(Q1, IF:8.8)
[4]Weilin Zeng, Yingqiu Song, Runze Wang, Rong He,Tianlu Wang*, Neutrophil elastase: From mechanisms to therapeutic potential,Journal of Pharmaceutical Analysis.7 January 2023.(Q1,IF:14)
[5] Yingying Yuan, Bo Liu, Tianlu Wang*, Na Li, Zhengyao Zhang, Hangyu Zhang*, Electrochemical microfluidic paper-based analytical devices for tumor marker detection, TrAC Trends in Analytical Chemistry. 2022, 157:116816.(Q1,IF:14)
[6] Yingying Yuan, Bo Liu, Hui Li, Mo Li , Yingqiu Song, Runze Wang, Tianlu Wang*, Hangyu Zhang*, Flexible Wearable Sensors in Medical Monitoring, Biosensors. 2022, 12: 1069.(Q2,IF: 5.8)
[7] Jin G, Wang R, Jin Y, Song Y, Wang T. From intramuscular to nasal: unleashing the potential of nasal spray vaccines against coronavirus disease 2019. Clin Transl Immunology. 2024;13(5):e1514. (Q2,IF: 5.8)
[8]Wang Y, Song Y, Wang R, Wu Y, Li M, Xu K, He R, Wang Z, Li Q, Kong FS, Wang T. Clinical factors and major pathological response after neoadjuvant chemoimmunotherapy in potentially resectable lung squamous cell carcinoma. Front Oncol. 2024 Apr 12;14:1265228. doi: 10.3389/fonc.2024.1265228. (Q3, IF:4.7)
[9] Li J, Zhang X, Wang Y, Jin Y, Song Y and Wang T. Clinicopathological characteristics and prognosis of synchronous brain metastases from non-small cell lung cancer compared with metachronous brain metastases. Front Oncol. 2024 May; 14:1400792. doi: 10.3389/fonc.2024.1400792.(Q3, IF:4.7)
[10]Zhang X, Che X, Zhang S, Wang R, Li M, Jin Y, Wang T, Song Y. Mesenchymal stem cell-derived extracellular vesicles for human diseases. Extracell Vesicles Circ Nucleic Acids 2024;5:64-82. https://dx.doi.org/10.20517/evcna.2023.4
[11] Chensen Liu, Yingqiu Song†, Runze Wang, Zheng Wang, Rong He, Ke Xu, Chenyu Wang, Yu Wu,Ye Wang, Xiaofang Zang, Gaung Li, Tianlu Wang*, Thorax radiotherapy using 18F-positron emission tomography/computed tomography-guided precision radiotherapy is a prognostic factor for survival in patients with extracranial oligometastatic non-small cell lung cancer:A two-center propensity score-matched analysis, Front. Oncol. 2022,12:991378.(Q3,IF:5.8)
[12] Xiaofang Zhang, Tianlu Wang†, Chenyu Wang, Yingqiu Song*, Comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from SCLC: study protocol for a randomized controlled trial, Trials. 2022, 23(1): 1-9.(Q4,IF:2.7)
[13] Nan Wang, Yun Qiao, Yingqiu Song†, Zheng Wang, Xia Li, Chengsen Liu, Ye Wang, Yu Wu, Rong He, Chenyu Wang, Yangwu Ren, Guang Li, Tianlu Wang*, In 18F-positron emission tomography/computed tomography-guided precision radiotherapy for centra-lly located non-small cell lung cancer, tumor related atelectasis is a prognostic factor of survival: Bicentral Propensity Score Maching Analysis, Frontiers in Oncology. 2022;12:2234-943X. (Q3,IF: 5.8)
[14] Xiaofang Zhang, Sibo Zhang, Tianlu Wang*, How the mechanical microenvironment of stem cell growth affects their differentiation: a review. Stem Cell Res Ther. 2022,13:415.(Q2,IF: 8.1)
[15] Xiaofang Zhang, Donggang Xu, Tianlu Wang*, Research Progress in the Application of Exosomes in Immunotherapy, Front Immunol. 2022, 15(13):731516. (Q2,IF: 7.5)
[16] Siqi Zhang, Junwei Ye, Tianlu Wang, Guiling Ning, Dual Stimuli-Responsive smart fibrous membranes for efficient Photothermal/Photodynamic/Chemo-Ther-apy of Drug-Resistant bacterial infection,Chemical Engineering Journal. 2022, 432:27. (Q1,IF: 13.3)
[17] Shuang Ma, Xiaofang Zhang, Dan Dang, Wenxue Wang, Tianlu Wang*, Dynamic Characterization of Sin-gle Cells Based on Temporal Cellular Mechanical Properties, IEEE Transactions on Nanobioscience. 2023,22(1):19-27.. (Q3,IF: 3.2)
[18] Xiaofang Zhang, Tianlu Wang†, Xinyan Xiao, Xia Li, Chen Yu Wang, Bo Huang, Lei He, Yingqiu Song*, Radiotherapy for head and neck tumours using an oral fixation and parameter acquisition device and TOMO technology: a randomised controlled study, BMJ open. 2021, 11(11): e052542.(Q3,IF: 2.7)
[19] Shuang Ma, Wenxue Wang, Yuechao Wang, Lianqing Liu, Tianlu Wang*, A New Method for Characteri-zation of Single Cell Using System Identification, 2021 IEEE International Conference on Nano-Micro Eng-ineered and Molecular Systems NEMS, 2021. (EI)
[20] Yingqiu Song†, Nan Wang, Yun Qiao, Lei He, Xia Li, Xiaofang Zhang, Qiankun Yang, Runze Wang, Rong He, Chenyu Wang, Yangwu Ren, Guang Li, Tianlu Wang*, Treatment patterns and survival after 18F-fuorodeoxyglucose positron emission tomography/com-puted tomography-guided local consolidation therapy for oligometastatic non-small cell lung cancer: a two center propensity score matched analysis, Journal of Cancer Research and Clinical Oncology. 2020, 146: 1021-1031. (Q3,IF: 3.3)
[21] Hongting Ma, Qian Zhao, Peihao Cheng, Xiaodong Geng, Huannuo Tao,
Zhouxiaolong Zhang, Yue Jiang, Junlin Ma, Kai Yang, Quanli Liu,Hanwen Zhang,Zhida Liang, Jian Li*, Tianlu Wang*, Mianqi Xue*, Nan Zhu*,Wood-derived flexible supercapacitors for anti-freezing green power sources†,Journal of Materials Chemistry A.2024. (Q1,IF: 10.7)
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